From the A1 (Milan-Rome) From the North: Coming from the North highway, exit at “Firenze Nord”. Follow the signs to “ Center” / “Viali di Circonvallazione” and along the Fortezza da Basso, take Viale Spartaco Lavagnini. At the first traffic light turn right into Via Santa Caterina d'Alessandria towards Stazione Santa Maria Novella (SMN) until you find a square on your right (Piazza Indipendenza). Passing the square go straight on Via Nazionale and then turn left onto Via Guelfa following the signs that indicate the paking lot of Mercato Centrale. Turn right at first street (Via Panicale) and then immediately turn left onto Via Taddea, where after 150 meters on the left, at number 8 black, is located the Hotel Botticelli. In Florence, numbers are divided into black and red numbers: as a rule, black numbers are assigned to homes and hotels, and red numbers to businesses.

Coming from the South: exit at “Firenze Sud”. Follow the signs to “Center” / “Viali di Circonvallazione” until Piazza della Libertà. Take Via Lorenzo il Magnifico and at the first traffic light turn left onto Via Agnolo Poliziano. Continue straight across the Viale Spartaco Lavagnini and in front take Via Santa Caterina d'Alessandria towards Stazione Santa Maria Novella (SMN) until you find a square on your right (Piazza Indipendenza). Passing the square go straight onto Via Nazionale and then turn left into Via Guelfa following the signs that indicate the parking of Mercato Centrale. Turn right at first street (Via Panicale) and then immediately turn left onto Via Taddea, where after 150 meters on the left, at number 8 black, is located the Hotel Botticelli. In Florence, numbers are divided into black and red numbers: as a rule, black numbers are assigned to homes and hotels, and red numbers to businesses.

From the Amerigo Vespucci Airport of Florence : Hotel Botticelli is reachable by taxi in about 20 minutes, at the approximate cost of 20-25 euros. Alternatively, you can take the bus "Vola in Bus", a shuttle service that connects in about 25 minutes, with a frequency of half an hour, the airport - first arrivals (from 6.00 to 23.30) and the Central Station of Santa Maria Novella (SMN) - SITA bus station (from 5.30 to 23.00). The ticket (4.50 Euros) may be purchased on board, at the Sita Bus station, or at the information booth of ATAF Terminal in Piazza Stazione, Florence. From Santa Maria Novella, Hotel Botticelli is reachable on foot in about 10 minutes following the "By train" directions as outlined above.

From the Galileo Galilei Airport of Pisa : you can reach the center of Florence in about 1 hour and 20 minutes with the train that connects (directly or by connecting at Pisa Centrale station) the airport of Pisa with the Central Station of Santa Maria Novella ( SMN) in Florence. Tickets can be purchased at the Tourist Information Office in the Arrivals Hall of the airport. The railway station is located just outside the Check-In Hall. Another possibility is to use the Terravision bus that in about 70 minutes will bring you in front of the station of Santa Maria Novella in Florence (Via Alamanni side). Tickets can be purchased at the Information Office of the airport (Arrivals Terminal). The buses leave from outside the airport arrivals. Once you arrive at the station of Santa Maria Novella, Hotel Botticelli is reachable on foot in about 10 minutes following the "By train" directions as outlined above.

From the Central Train Station of Santa Maria Novella (SMN) : the Botticelli Hotel is easily reached on foot in about 10 minutes (distance about 500 meters). Arriving at the station you'll find two exits. Leaving the train tracks behind you, head towards the exit on the left (near the pharmacy). At the traffic light cross the road, turn right and go straight to the corner. Then turn left at Largo Fratelli Alinari.. After a few meters, the road changes name to Via Nazionale where you will stay until the third street on your right (Via Chiara). Turn right and go straight to Piazza del Mercato Centrale. At the bottom of the square, turn left into Via Rosina, and after 50 meters at the intersection with Via Taddea, you will be on the doorstep of Hotel Botticelli. If you prefer to take a taxi, the approximate cost from Santa Maria Novella to Hotel Botticelli is around 10-15 euro.